Le criblage avec une plate-forme NMNAT2-MSD identifie les petites molécules qui modulent les niveaux de NMNAT2 dans les neurones corticaux.
Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is a key neuronal maintenance factor and provides potent neuroprotection in many preclinical models of neurological disorders. NMNAT2 is significantly reduced in Alzheimer’s, Huntington’s and Parkinson’s diseases. Here, we have developed a discovery-based mesoscale (MSD) screening platform to quantify endogenous NMNAT2 in cortical neurons. The high sensitivity and large … Read more